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Research Description
Genomic changes at the ends of chromosomes are a major source of diversity and disease. We are interested in the structure and function of subtelomeres: regions at the ends of chromosomes adjacent to telomere repeats. Subtelomeres are a particularly dynamic part of the human genome, subject to rampant double-strand breaks (DSBs) and DNA transfers. The Rudd lab investigates the mechanism of breakage at chromosome ends, in search of DNA sequence motifs that promote genomic instability.
Areas of Specialization / Research Interests
Subtelomeres
Chromosome breakage
Chromosome biology
Genome evolution
Education
2007 Fellowship in Medial Genetics, University of Washington, Seattle, WA
2005 Ph.D., Genetics, Case Western Reserve University, Cleveland, OH
1998 B.S., Biology, The College of William and Mary, Williamsburg, VA
Board Certifications
2007 Clinical Cytogenetics, American Board of Medical Genetics
Selected Publications
Rudd, M.K., Keene, J., Bunke, B., Kaminsky, E.B., Adam, M., Mulle, J., Ledbetter, D.H., Martin, C.L. 2009. Segmental duplications mediate novel, clinically relevant chromosome rearrangements. Human Molecular Genetics doi: 10.1093/hmg/ddp233.
Rudd, M.K., Endicott, R., Friedman, C., Walker, M., Young, J.M., Osoegawa, K., NISC Comparative Sequencing Program, de Jong, P.J., Green, E.D., and Trask, B.J. 2009. Comparative sequence analysis of primate subtelomeres originating from a chromosome fission event. Genome Research 19: 33-41.
Rudd, M.K., Friedman, C., Parghi, S.S., Linardopoulou, E.V., Hsu, L., and Trask, B.J. 2007. Elevated rates of sister chromatid exchange at chromosome ends. PLoS Genetics 3: 319-323.
Rudd, M.K., Wray, G.A., and Willard, H.F. 2005. The evolutionary dynamics of alpha satellite. Genome Research 16: 88-96.
Rudd, M.K. and Willard, H.F. 2004. Analysis of the centromeric regions of the human genome assembly. Trends in Genetics 11: 529-533. (peer-reviewed genome analysis article)
Rudd, M.K., Mays, R.W., Schwartz, S., and Willard, H.F. 2003. Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag. Molecular and Cellular Biology 23: 7689-7697.
Schueler, M.G., Higgins, A.W., Rudd, M.K., Gustashaw, K., and Willard, H.F. 2001. Genomic and genetic definition of a functional human centromere. Science 294: 109-115.
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