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Research Description
Genomic variation is a major source of human diversity and disease. We focus on variation at the chromosome level, investigating the mechanisms of DNA breakage and repair that generate deletions, duplications, translocations, and more complex chromosome rearrangements. We also study the impact of chromosome rearrangements on nearby genes and chromatin environments. Our goal is to unravel the mechanisms and epigenetic effects of human chromosome rearrangements.
Areas of Specialization / Research Interests
Subtelomeres
Chromosome breakage
DNA repair
Chromosome biology
Genome evolution
Education
2007 Fellowship in Medial Genetics, University of Washington, Seattle, WA
2005 Ph.D., Genetics, Case Western Reserve University, Cleveland, OH
1998 B.S., Biology, The College of William and Mary, Williamsburg, VA
Board Certifications
2007 Clinical Cytogenetics, American Board of Medical Genetics
Honors and Awards
2009 March of Dimes Basil
O’Connor Starter Scholar Research Award
Selected Publications
Hermetz, K.E., Surti, U., Cody, J.D., Rudd, M.K. 2012. A recurrent translocation is mediated by homologous recombination between HERV-H elements. Molecular Cytogenetics 5(1):6.
Luo, Y.,+ Hermetz, K.E.,+ Jackson, J.M., Mulle, J.G., Dodd, A., Tsuchiya, K.D., Ballif, B.C., Shaffer, L.G., Cody, J.D., Ledbetter, D.H., Martin, C.L., Rudd, M.K. 2011. Diverse mutational mechanisms cause pathogenic subtelomeric rearrangements. Human Molecular Genetics 1;20(19):3769-3778.
+These authors contributed equally to this work.
Rudd, M.K., Keene, J., Bunke, B., Kaminsky, E.B., Adam, M., Mulle, J., Ledbetter, D.H., Martin, C.L. 2009. Segmental duplications mediate novel, clinically relevant chromosome rearrangements. Human Molecular Genetics 18(16):2957-2962.
Rudd, M.K., Endicott, R., Friedman, C., Walker, M., Young, J.M., Osoegawa, K., NISC Comparative Sequencing Program, de Jong, P.J., Green, E.D., and Trask, B.J. 2009. Comparative sequence analysis of primate subtelomeres originating from a chromosome fission event. Genome Research 19: 33-41.
Rudd, M.K. 2007. Subtelomeres; evolution in the human genome. In: ENCYCLOPEDIA OF LIFE SCIENCES. John Wiley & Sons, Ltd. Edited by Kehrer-Sawatzki, H., pp. 1-9.
Rudd, M.K., Friedman, C., Parghi, S.S., Linardopoulou, E.V., Hsu, L., and Trask, B.J. 2007. Elevated rates of sister chromatid exchange at chromosome ends. PLoS Genetics 3: 319-323.
Doggett, N.A., Xie, G., Meincke, L.J., Sutherland, R.D., Mundt, M.O., Berbari, N.S., Davy, B.E., Robinson, M.L., Rudd, M.K., Weber, J.L., Stallings, R.L., and Han, C. 2006. A 360 kb interchromosomal duplication of the human HYDIN locus. Genomics 88: 762-771.
Rudd, M.K., Wray, G.A., and Willard, H.F. 2005. The evolutionary dynamics of alpha satellite. Genome Research 16: 88-96.
Rudd, M.K., Mays, R.W., Schwartz, S., and Willard, H.F. 2003. Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag. Molecular and Cellular Biology 23: 7689-7697.
Schueler, M.G., Higgins, A.W., Rudd, M.K., Gustashaw, K., and Willard, H.F. 2001. Genomic and genetic definition of a functional human centromere. Science 294: 109-115.
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