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Research Description
My research focuses on statistical issues affecting genetic association
studies. Ongoing methodological work addresses 1) the impact of
genotype quality on the validity of different types of association
studies, 2) methods to adjust for the many correlated tests performed
in contemporary association studies, which may involve dense SNPs,
overlapping haplotypes, and/or related phenotypes, 3) extension of
these methods to meta-analyses, and 4) detection of copy number
variants in genome-wide array data. Current applied work includes
projects on the genetics of post-traumatic stress disorder, breast
cancer, essential tremor and Parkinson’s disease, and longevity.
Education
2008 Ph.D., Biostatistics, University of Michigan
1997 M.A., Economics, Princeton University
1994 B.S., Statistics, University of Illinois
Selected Publications
Conneely KN, Boehnke M (2007) So many correlated
tests, so little time! Rapid adjustment of p-values for multiple
correlated tests. American Journal of Human Genetics 81:1158-1168
Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos
MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ,
Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN,
Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark
CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe
RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN,
Tuomilehto J, Collins FS, Boehnke M (2007) A genome-wide association
study of type 2 diabetes in Finns detects multiple susceptibility
variants. Science 316:1341-1345
Willer CJ, Bonnycastle LL, Conneely KN,
Duren WL, Jackson AU, Scott LJ, Narisu N, Chines PS, Skol A, Stringham
HM, Petrie J, Erdos MR, Swift AJ, Enloe ST, Sprau AG, Smith E, Tong M,
Doheny KF, Pugh EW, Watanabe RM, Buchanan TA, Valle TT, Bergman RN,
Tuomilehto J, Mohlke KL, Collins FS, Boehnke M (2007) Screening of
134 single nucleotide polymorphisms (SNPs) previously associated with
type 2 diabetes replicates association with 12 SNPs in nine genes.
Diabetes 56:256-264
Bonnycastle LL, Willer CJ, Conneely KN,
Jackson AU, Burrill CP, Watanabe RM, Chines PS, Narisu N, Scott LJ,
Enloe ST, Swift AJ, Duren WL, Erdos MR, Riebow NL, Buchanan TA, Valle
TT, Tuomilehto J, Bergman RN, Mohlke KL, Boehnke M, Collins FS (2006)
Common variants in MODY genes contribute to risk of type 2 diabetes in
Finns. Diabetes 55:2534-2540
Mohlke KL, Jackson AU, Scott LJ, Peck EC, Suh YD, Chines PS, Watanabe RM, Buchanan TA, Conneely KN,
Erdos MR, Narisu N, Enloe S, Valle TT, Tuomilehto J, Bergman RN,
Boehnke M, Collins FS (2005) Mitochondrial polymorphisms and
susceptibility to type 2 diabetes-related traits in Finns. Human
Genetics 118:245-254
Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN,
Gordon LB, Der CJ, Cox AD, Collins FS (2005) Inhibiting farnesylation
of progerin prevents the characteristic nuclear blebbing of
Hutchinson-Gilford progeria syndrome. Proceedings of the National
Academy of Sciences 102:12879-12884
Conneely KN,
Silander K, Scott LJ, Mohlke KL, Lazaridis KN, Valle TT, Tuomilehto J,
Bergman RN, Watanabe RM, Buchanan TA, Collins FS, Boehnke M (2004)
Variation in the resistin gene is associated with obesity and
insulin-related phenotypes in Finnish subjects. Diabetologia
47:1782-1788
Silander K, Mohlke KL, Scott LJ, Peck EC,
Hollstein P, Skol AD, Jackson AU, Deloukas P, Hunt S, Stavrides G,
Chines PS, Erdos MR, Narisu N, Conneely KN,
Li C, Fingerlin TE, Dhanjal SK, Valle TT, Bergman RN, Tuomilehto J,
Watanabe RM, Boehnke M, Collins FS (2004) Genetic variation near the
hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type
2 diabetes. Diabetes 53:1141-1149 |