Tamara Caspary, Ph.D.

Associate Professor

Office: 305P

Lab: 365

Phone: 404-727-9862

Email: tamara.caspary@emory.edu

Additional Contact Information

Mailing Address:

Whitehead Biomedical Research Building

615 Michael St.

Atlanta, GA 30322

Additional Websites

Research Interests

We use the mouse to define how the mammalian nervous system develops. Through chemical mutagenesis we have identified over 20 recessive mutant lines with specific defects in the nervous system. In collaboration with Drs. Michael Zwick and David Cutler in the Department, we use deep resequencing to identify the genetic lesions in the lines. This approach is especially fruitful since it permits us to focus on novel genes. One of these, Arl13b, is localized to cilia and disrupts Sonic Hedgehog (Shh), a critical pathway for spinal cord development. In humans, defects in Arl13b can cause Joubert Syndrome and may underlie other cilia-related diseases. We combine biochemical, molecular, cellular and genetic approaches to figure out the mechanism underlying Arl13b function, as well as the other genes identified in the screen.

Areas of Specialization

  • Mammalian nervous system development

Education

  • BS, The University of North Carolina, 1992
  • PhD, Princeton University, 1999

Professional Memberships

  • Genetics Society Of America
  • Society for Developmental Biology
  • American Association of Cell Biology

Publications