Tamara Caspary, Ph.D.
Additional Contact Information
Whitehead Biomedical Research Building
615 Michael St.
Atlanta, GA 30322
We use the mouse to define how the mammalian nervous system develops. Through chemical mutagenesis we have identified over 20 recessive mutant lines with specific defects in the nervous system. In collaboration with Drs. Michael Zwick and David Cutler in the Department, we use deep resequencing to identify the genetic lesions in the lines. This approach is especially fruitful since it permits us to focus on novel genes. One of these, Arl13b, is localized to cilia and disrupts Sonic Hedgehog (Shh), a critical pathway for spinal cord development. In humans, defects in Arl13b can cause Joubert Syndrome and may underlie other cilia-related diseases. We combine biochemical, molecular, cellular and genetic approaches to figure out the mechanism underlying Arl13b function, as well as the other genes identified in the screen.
Areas of Specialization
- Mammalian nervous system development
- BS, The University of North Carolina, 1992
- PhD, Princeton University, 1999
- Genetics Society Of America
- Society for Developmental Biology
- American Association of Cell Biology
- View publications on PubMed