Bing Yao, PhD

Assistant Professor

Lab: Whitehead Biomedical Research Building 355

Email: bing.yao@emory.edu

Additional Contact Information

Mailing Address:

Whitehead Biomedical Research Building

615 Michael St

Atlanta, GA 30322

Additional Websites

Research Interests

Our long-term research interests are to understand the pivotal roles of epigenetic regulation, especially various forms of covalent DNA and RNA modifications, in normal brain functions, as well as how dysregulation of these processes may contribute to human brain disorders. By using the mouse as a primary model system, we combine genetics, molecular biology, biochemistry, cell biology and bioinformatics systems to continuously push the boundaries of our understanding regarding the molecular mechanisms of these epigenetic markers in the central nervous system (CNS).

 

DNA covalent modifications on the 5-carbon position of cytosine, such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), play key epigenetic roles in the mammalian CNS. Our data suggest 5hmC and its enzymatic “writer” are critical in shaping the epigenetic landscape related to mammalian neurogenesis. Genome-wide 5hmC is dysregulated in many neurodegenerative disorders, such as fragile X-associated tremor/ataxia syndrome (FXTAS). Our latest efforts focus on a novel DNA adenine methylation, N6-methyladenine (6mA), in metazoan CNS. By characterizing the genomic roles of 6mA, we find that 6mA could be involved in regulating neurodevelopment and stress response in the brain. Currently, we are working to further illustrate the precise molecular mechanisms of these DNA modifications in neurodevelopment and neuronal functions, as well as their roles in neurological, neurodegenerative and neuropsychiatric diseases.

Areas of Specialization

  • Epigenetic regulation in normal neuronal functions and brain disorders
  • Regulatory RNAs in the central nervous system
  • Human and mouse genetics
  • High-throughput sequencing analysis

Education

  • Ph.D, University of Florida, 2012
  • BS, Ocean University of China, 2002

Professional Memberships

  • American Society of Human Genetics
  • RNA society
  • American Society of Cell Biology

Publications