Michael E Zwick, Ph.D.
Departments of Human Genetics and Pediatrics
Assistant Dean of Research
Emory University School of Medicine
Assistant Vice President for Research
Robert W. Woodruff Health Sciences Center
Office: 331 Whitehead Biomedical Research Building
Lab: 335 Whitehead Biomedical Research Building
Additional Contact Information
Whitehead Biomedical Research Building
615 Michael St.
Atlanta, GA 30322
I use cutting-edge genomics technologies to identify rare genetic variation that contributes to common pediatric disorders. My main areas of interest include autism, congenital heart defects in Down syndrome, early-onset Inflammatory Bowel Disease (IBD), and juvenile arthritis. Current projects include:
Identifying Autism Susceptibility Genes: I am a member of the Autism Sequencing Consortium (ASC) and co-lead the membership committee for the ASC.
Copy Number Variation as a Cause of Congenital Heart Defects in Down Syndrome: The genetic causes of congenital heart defects (CHD) remain largely undiscovered. Individuals with trisomy 21, the cause of Down Syndrome, have much higher rates of CHD, including the very severe atrioventricular septal defects (AVSD). Our project aims to identify both structural genetic variation and common single nucleotide polymorphisms that act to increase the risk of AVSD. Identifying the genetic basis of this disorder can provide insights into the origins of CHD and ultimately lead to improved methods of treatment and prevention.This work is funded by both the National Institutes of Health/National Heart, Lung and Blood Institute (http://www.nhlbi.nih.gov/)
Early-onset forms of Inflammatory Bowel Disease (IBD): With collaborators Subra Kugathasan, David Cutler, Mike Epstein.
Software Tools We Have Developed With Collaborators:
SeqAnt - Sequence Annotator (http://seqant.genetics.emory.edu/)
MOPed - Microarray Oligonucleotide Probe Designer (http://moped.genetics.emory.edu/)
My Graduate Programs at Emory
Graduate Program in Population Biology, Ecology and Evolution (PBEE)
Graduate Program in Genetics and Molecular Biology (GMB)
Areas of Specialization
- Human Disease Gene Mapping
- Population Biology, Population Genetics, Population Genomics
- Methods of Targeted Enrichment and Next Generation Sequencing
- Open Source Software Tools for Genomics
- Postdoctoral Fellow, Johns Hopkins University School of Medicine, 2000-2002
- Postdoctoral Fellow, Case Western Reserve University School of Medicine, 1999-2000
- PhD, University of California at Davis, Davis, CA,1993-1998
- BS, Cornell University, Ithaca, NY,1985-1989
- View publications on Scholar Google