Epstein software page
Chaplin is software for identifying specific haplotypes or
haplotype features that are associated with disease using genotype
data from a case-control study. The program utilizes statistical
methodology initially developed in
Epstein and Satten (2003) and
explored further in
Satten and Epstein (2004).
Chaplin is a Win32 application written in FORTRAN 90 using IMSL
numerical routines and has been tested on both Windows XP and 2000
machines. The software has not been tested on earlier versions of the
Windows OS or on UNIX platforms but it is unlikely that Chaplin will
perform correctly on these systems.
Scout is a software program for conducting combined association
analysis of triads and unrelated subjects. The software utilizes
statistical methodology developed in
Epstein et al. (2005).
LSKM consists of a R routine that allow for semiparametric association
testing of quantitative traits with multiple SNP predictors, adjusting
for environmental covariates. The software implements statistical
methodology recently developed in
Kwee et al. (2008).
The downloaded zipped file will contain the R routine, documentation, and example
input files.
StratScore: Software that controls for population stratification in case-control association studies
StratScore is a software package for genetic association mapping of
disease that corrects for the confounding effects of population
stratification. The software is based on a variation of the methods
described in the paper of
Epstein et al. (2007). Please refer to this
paper for a description of the underlying statistical methods.
Currently, the StratScore software is only available as a set of SAS
routines. In the near future, we intend to release a self-contained
version of the software that can run either via a graphic-user
interface or a terminal interface.
Chaplin: Case-control haplotype inference package.
Scout: Software for association
analysis of triads and unrelated subjects