Chaplin: Case-control haplotype inference package
- Development Status: version 1.2.3
- Environment: Win32 (MS Windows 2000/XP)
- Intended Audience: Epidemiologists, geneticists
- Operating System: MS Windows 2000 & XP
- Programming Language: Fortran 90
- Topic: Statistical genetics
Description of project:
Chaplin is a software program for identifying specific haplotypes or
haplotype features that are associated with disease using genotype
data from a case-control study. The program utilizes statistical
methodology initially developed in Epstein and Satten (2003) and
explored further in Satten and Epstein (2004). For a thorough
description of the statistical methodology, please review these papers
(which are available for download below).
Chaplin is a Win32 application written in FORTRAN 90 using IMSL
numerical routines and has been tested on both Windows XP and 2000
machines. The software has not been tested on earlier versions of the
Windows OS or on UNIX platforms but it is unlikely that Chaplin will
perform correctly on these systems.
Epstein MP and Satten GA (2003).
Inference on haplotype effects in case-control studies using unphased
Am. J. Hum. Genet. 73:1316-1329
Satten GA and Epstein MP (2004).
Comparison of prospective and retrospective methods for haplotype
inference in case-control studies.
Genet Epidemiol. 2004 Nov; 27(3):192-201