Emory University School of Medicine Epstein software
Chaplin project:

Chaplin   Chaplin:    Case-control haplotype inference package


Description of project:

Chaplin is a software program for identifying specific haplotypes or haplotype features that are associated with disease using genotype data from a case-control study. The program utilizes statistical methodology initially developed in Epstein and Satten (2003) and explored further in Satten and Epstein (2004). For a thorough description of the statistical methodology, please review these papers (which are available for download below).

Chaplin is a Win32 application written in FORTRAN 90 using IMSL numerical routines and has been tested on both Windows XP and 2000 machines. The software has not been tested on earlier versions of the Windows OS or on UNIX platforms but it is unlikely that Chaplin will perform correctly on these systems.

Associated publications

Epstein MP and Satten GA (2003). Inference on haplotype effects in case-control studies using unphased genotype data. Am. J. Hum. Genet. 73:1316-1329

Satten GA and Epstein MP (2004). Comparison of prospective and retrospective methods for haplotype inference in case-control studies. Genet Epidemiol. 2004 Nov; 27(3):192-201

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