Publications

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2015

Umberger NL, and Caspary T.  Mol Biol Cell. 2015, Jan 15;26(2):350-8. Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of rapamycin signaling and diminished PP2A activity.

Thomas S, Cantagrel V, Mariani L, Serre V, Lee JE, Elkhartoufi N, de Lonlay P, Desguerre I, Munnich A, Boddaert N, Lyonnet S, Vekemans M, Lisgo SN, Caspary T, Gleeson J, Attié-Bitach T. Eur J Hum Genet. 2015, May;23(5):621-7. Identification of a novel ARL13B variant in a Joubert syndrome-affected patient with retinal impairment and obesity.

2013

Piotrowska-Nitsche K1, Caspary T. J Vis Exp. 2013, Apr 30;(74):e4439. Ex vivo live imaging of single cell divisions in mouse neuroepithelium.

Higginbotham H, Guo J, Yokota Y, Umberger NL, Su CY, Li J, Verma N, Hirt J, Ghukasyan V, Caspary T, Anton ES. Nat Neurosci. 2013, Aug;16(8):1000-7. Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation.

2012

Higginbotham H, Eom TY, Mariani LE, Bachleda A, Hirt J, Gukassyan V, Cusack CL, Lai C, Caspary T, Anton ES. Developmental Cell. 2012, Nov 13 23(5):925-38. Arl13b in primary cilia regulates the migration and placement of interneurons in the developing cerebral cortex.

Su CY, Bay SN, Mariani LE, Hillman MJ, Caspary T. Development. 2012, Nov 139(21):4062-71. Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time.

Bay SN, Caspary T. Cilia. 2012, 1 Oct,1:19. What are those cilia doing in the neural tube?

Larkins CE, Busey Long A, Caspary T. Dev Biol. 2012 Jul 1;367(1):15-24. Defective Nodal and Cerl2 expression in Arl13b(hnn) mutant node underlies its heterotaxia.

Piotrowska-Nitsche K, Caspary T. Cilia. 2012 May 2,1:6. Live imaging of individual cell divisions in mouse neuroepithelium shows asymmetry in cilium formation and Sonic hedgehog response.

Sun M, Mondal K, Patel V, Horner VL, Long AB, Cutler DJ, Caspary T, Zwick ME. G3 January 2012 2:143-150. Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutation in the Mouse.

2011

Larkins CE, Aviles GDG, East MP, Kahn RA, Caspary T. Mol Biol Cell. 2011 Dec;22(23):4694-703. Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins.

Horner VL, Caspary T. Dev Biol. 2011. Jul 1;355(1):43-54. Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling.

Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Haken R, Caspary T, Mocarski ES. Nature. 2011 Mar 17;471(7338):368-72. RIP3 mediates the embryonic lethality of caspase-8-deficient mice.

Horner VL, Caspary T. Methods Mol Biol. 2011;770:313-36. Creating a hopeful monster: mouse forward genetic screens. 

2010

Moore BA, Gonzalez Aviles GD, Larkins CE, Hillman MJ, Caspary T. Mamm Genome. 2010 Aug;21(7-8):350-60. Mitochondrial retention of Opa1 is required for mouse embryogenesis

2009

Tapanes-Castillo A, Weaver EJ, Smith RP, Kamei Y, Caspary T, Hamilton-Nelson KL, Slifer SH, Martin ER, Bixby JL, Lemmon VP. Neurogenetics. 2012 Feb;11(1):53-71. A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice. 

2008

Cantagrel V, Silhavy JL, Bielas SL, Swistun D, Marsh SE, Bertrand JY, Audollent S, Attié-Bitach T, Holden KR, Dobyns WB, Traver D, Al-Gazali L, Ali BR, Lindner TH, Caspary T, Otto EA, Hildebrandt F, Glass IA, Logan CV, Johnson CA, Bennett C, Brancati F; International Joubert Syndrome Related Disorders Study Group, Valente EM, Woods CG, Gleeson JG. Am J Hum Genet. 2008 Aug;83(2):170-9. Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome.

2007

Caspary T, Larkins CE, Anderson KV. Dev Cell. 2007 May;12(5):767-78. The graded response to Sonic Hedgehog depends on cilia architecture.

Alisch RS, Jin P, Epstein M, Caspary T, Warren ST. PLoS Genet. 2007 Dec 28;3(12):e227. Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation.

2006

Caspary T, Anderson KV. Dev Dyn. 2006 Sep;235(9):2412-23. Uncovering the uncharacterized and unexpected: unbiased phenotype-driven screens in the mouse. (Review)

2005

García-García MJ, Eggenschwiler JT, Caspary T, Alcorn HL, Wyler MR, Huangfy D, Rakeman AS, Lee JD, Feinberg EH, Timmer JR, Anderson KV. Proc Natl Acad Sci USA. 2005 Apr 26;102(17):5913-9. Anaylsis of mouse embryonic patterning and morphogenesis by forward genetics.

2003

Caspary T, Anderson KV. Nat Rev Neurosci. 2003 Apr;4(4):289-97. Patterning cell types in the dorsal spinal cord: what the mouse mutants say. (Review)

2002

Caspary T, García-García MJ, Eggenschwiler JR, Wyler MR, Huangfu D, Rakeman AS, Lee JD, Alcorn HL, Anderson KV. Curr Biol. 2002 Sep 17;12(18):1628-32. Mouse Dispatched homologue1 is required for long-range, but not juxtacrine, Hh signaling.

1999

Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, and Tilghman SM. Genes Dev. 1999 Dec 1;13(23):3115-24. Oppositely imprinted genes p57Kip2 and Igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.

1998

Tilghman SM, Caspary T, Ingram RI. Nature Genetics. 1998. 18:206-208. Competitive edge at the imprinted Prader-Willi/Angelman region.

Caspary T, Cleary MA, Baker CC, Guan XJ, Tilghman SM. Mol Cell Biol. 1998 Jun;18(6):3466-74. Multiple mechanisms of imprinting on distal mouse chromosome 7.

1995

Guillemot FT, Caspary T, Tilghman SM, Copeland NG, Gilbert DJ, Jenkins NA, Anderson DJ, Joyner AL, Rossant J, Nagy A. Nat Genet. 1995 Mar;9(3):235-42. Genomic imprinting of Mash-2, a mouse gene required for trophoblast development.