Publications

2012

66. Qurashi, A., Li, H., Ray, L., Nelson, D.L., Duan, R., and Jin, P. (2012) Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Human Molecular Genetics, Accepted.

65. Tan, H., Xu, Z., and Jin, P. (2012) Role of noncoding RNAs in trinucleotide repeat neurodegenerative disorders. Experimental Neurology, In Press.

64. Irier, H. and Jin, P. (2012) Dynamics of DNA Methylation in Aging and Alzheimer’s Disease. DNA and Cell Biology, In Press.

2011

63. Qurashi, A., Li, X. and Jin, P. (2011) Fragile X Mental Retardation Protein and Stem Cells. Modeling Fragile X Syndrome. [PDF]

62. Szulwach, K.E., Li, X., Li, Y., Song, C.X., Wu, H., Dai, Q., Irier, H., Upadhyay, A.K., Gearing, M., Levey, A.I., Vasanthakumar, A., Godley, L.A., Chang, Q., Cheng, X., He, C. and Jin, P. (2011) 5-hydroxymethylcytosine-mediated epigenetic dynamics during neurodevelopment and aging. Nature Neuroscience, 14: 1607-1616. [PDF]

61. Tan, H., Qurashi, A., Nelson, D.L., Li, H., and Jin, P. (2011) Retrotransposon activation is involved in fragile X premutation rCGG-mediated neurodegeneration. Human Molecular Genetics, 21: 57-65. [PDF]

60. Szulwach, K.E., Li, X., Li, Y., Song, C.X., Han, J.W., Kim, S., Namburi, S., Hermetz, K., Kim, J.J., Rudd, M.K., Yoon, Y., Ren, B., He, C. and Jin, P. (2011) Integrating 5-hydroxymethylcytosine into the Epigenomic Landscape of Human Embryonic Stem Cells. PLoS Genetics, 7(6): e1002154. [PDF] SEQ Data at NCBI

59. Guo, W., Zhang, L., Christopher, D.M., Teng, Z.Q., Fausett, S.R., Liu, C., George, O.L., Klingensmith, J., Jin, P. and Zhao, X. (2011) RNA-Binding Protein FXR2 Regulates Adult Hippocampal Neurogenesis by Reducing Noggin Expression. Neuron, 70: 924-938. [PDF]

58. Qurashi, A., Li, W., Zhou, J.Y., Peng, J., and Jin, P. (2011) Nuclear Accumulation of Stress Response mRNAs Contributes to the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats. PLoS Genetics, 7(6): e1002102. [PDF]

57.Guo, W., Allan, A.M., Zong, R., Zhang, L., Johnson, E.B., Schaller, E.G., Murthy, A.C., Goggin, S.L., Eisch, A.J., Ooostra, B.A., Nelson, D.L., Jin, P. and Zhao, X. (2011) Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning. Nature Medicine, 17(5): 559-65. [PDF]

56. Vitale, A.V., Tan, H. and Jin, P. (2011) MicroRNAs, SNPs and Cancer. Journal of Nucleic Acids Investigation, 2: 32-38. [PDF]

55. Song, C.X., Szulwach, K.E., Fu, Y., Dai, Q., Yi, C., Li, X., Li, Y., Chen, C.H., Zhang, W., Jian, X., Wang, J., Zhang, L., Looney, T.J., Zhang, B., Godley, L.A., Hicks, L.M., Lahn, B.T., Jin, P.*, and He, C*. (2010) Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nature Biotechnology, 29(1): 68-72. (*: Co-Corresponding authors). [PDF]

2010

54. Li, Y., He, C. and Jin, P. (2010). Emergence of Chemical Biology Approaches to the RNAi/miRNA Pathway. Chemistry & Biology, 17(6): 584-589. [PDF]

53. Smrt, R.D., Szulwach K. E., Pfeiffer, R.L., Li, X., Guo, W., Pathania, M., Luo, Y., Peng, J., Wilson, M.C., Bordey, A., Jin, P.*, and Zhao, X.* (2010) MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase Mind Bomb-1. Stem Cells, 28(6): 1060-1070. (*: Co-Corresponding authors). [PDF]

52. Liu, C., Teng, Z. Q., Satistevan, N.J., Szulwach, K. E., Guo, W., Jin, P., and Zhao, X. (2010) Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell. [PDF]

51. Luo, Y., Shan, G., Smrt, R.D., Li, X., Duan, R., Barkho, B.Z., Li, W., Jin, P.*, and Zhao, X.* (2010) Fragile X mental retardation protein regulates adult neurogenesis. PLoS Genetics. (*: Co-Corresponding authors). [PDF]

50. Szulwach K. E., Li, X., Smrt, R.D., Li, Y., Luo, Y., Lin, L., Satistevan, N.J., Li, W. Zhao, X., and Jin, P. (2010) MeCP2-mediated crosstalk between microRNA and epigenetic regulation in adult neurogenesis. Journal of Cell Biology. [PDF]

49. Li, X. and Jin, P. (2010). Roles of small regulatory RNAs in the determination of neuronal identity. Nature Reviews Neuroscience. [PDF]

48. Qurashi, A. and Jin, P. (2010). Small RNA-mediated Gene Regulation in Neurodevelopmental Disorders. Current Psychiatry Reports. [PDF]

47. Lin, L., Vitale, A.V., and Jin, P. (2010). Small RNAs in Neurological Disorders. The Encyclopedia of Life Sciences, [PDF]

2009

46. Li, X. and Jin, P. (2009). Macro Role(s) of MicroRNAs in Fragile X Syndrome? NeuroMolecular Medicine, 11: 200-207. [PDF]

45. Tan, H., Li, H., and Jin, P. (2009). RNA-mediated pathogenesis in fragile X-related disorders. Neuroscience Letters, 466, 103-108. [PDF]

44. Yang, Y., Xu, S., Xia, L., Wang, J., Jin, P.* and Chen, D.* (2009) MicroRNA Bantam is associated with Drosophila Fragile X mental retardation protein and regulates the fate of germline stem cells. PLoS Genetics, 5(4): e1000444. (*: Co-Corresponding authors) [PDF]

43. Li, W., Duan, R., Kooy, F., Sherman, S.L., Zhou, W. and Jin, P. (2009) Germline mutation of microRNA-125a is associated with breast cancer. Journal of Medical Genetics, 46, 358-360. [PDF]

42. Chang, S., Wen, S., Chen, D. and Jin, P. (2009). Small Regulatory RNAs in Neurodevelopmental Disorders, Human Molecular Genetics, 18, R18-R26. [PDF]

41. Szulwach, K.E., Jin, P. and Alisch, R. Noncoding RNAs in mental retardations. (2009). Clinical Genetics, 75, 209-219. [PDF]

2008

40. Shan, G.*, Li, Y.* (*Equal Contribution), Zhang, J., Li, W., Szulwach, K., Duan, R., Faghihi, M.A., Khalil, A., Lu, L., Paroo, Z., Chan, A.W.S., Shi, Z., Liu, Q., Wahlestedt, C., He, C., and Jin, P. (2008). A small molecule enhances RNA interference and promotes microRNA processing. Nature Biotechnology, 8, 933-940. [PDF]

39. Li, Y., Lin, L., and Jin, P. (2008). The microRNA pathway and Fragile X Mental Retardation Protein. BBA-Gene Regulatory Mechanism, 1779, 702-705. [PDF]

38. Szulwach, K.E. and Jin, P. (2008). Epigenetic Regulation of miRNA in Stem Cells. Current Perspective in miRNAs.

37. Shan, G. and Jin, P. (2008). RNA Interference to Treat Human Diseases, Applications of. Wiley Encyclopedia of Chemical Biology.

36. Allan, A.M., Liang, X., Luo, Y., Pak, C., Li, X., Szulwach, K.E., Chen, D., Jin, P., and Zhao, X. (2008). The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Human Molecular Genetics, 17, 1-11. [PDF]

35. Shan, G., Xu, S., and Jin, P. (2008). FXTAS, a bad RNA and a hope for cure. Expert Opinion on Biological Therapy, 8, 249-253. [PDF]

34. Chang, S., Bray, S.M., Li, Z., Zarnescu, D.C., He, C., Jin, P., and Warren, S.T. (2008). Identification of small molecules rescuing morphological, biochemical and behavioral phenotypes of fragile X syndrome in Drosophila. Nature Chemical Biology, 4, 256-263. [PDF]

2007

33. Alisch, R.S., Jin, P., Epstein, M., Caspary, T., and Warren, S.T. (2007). Argonaute2 is Essential for Mammalian Gastrulation and Proper Mesoderm Formation. PLoS Genetics, 3, 2565-2571. [PDF]

32. Satterlee, J., Barbee, S., Jin, P., Krichevsky, A., Salama, S., Schratt, G. and Wu, D.Y. (2007). Non-coding RNAs in the Brain. Journal Of Neuroscience, 27, 11856-11859. [PDF]

31. Yang, L., Chen, D., Duan, R., Xia, L., Wang, J., Qurahsi, A., Jin, P.*, and Chen, D.* (2007). Argonaute protein regulates the fate of germline stem cell in Drosophila. Development, 134, 4265-4272. (*: Co-Corresponding authors) [PDF]

30. Jang, S.W., Okada, M., Sayeed, I., Stein, D., Jin, P., and Ye, K. (2007). Gambogic Amide, A Selective Agonist for TrkA Receptor that Possesses Robust Neurotrophic Activity, Prevents Neuronal Cell Death. Proc Natl Acad Sci U S A, 104, 16329-16334. [PDF]

29. Choe, E., Liao, L., Cheng, D., Duong, D.M., Jin, P., Tsai, L.H., and Peng, J. (2007). Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. Journal Of Neuroscience, 27, 9503-9512. [PDF]

28. Qurahsi, A., Chang, S. and Jin, P. (2007). Role of MicroRNA pathway in Mental Retardation. TheScientificWorld, 7, 146-154. [PDF]

27. Sofola, O.A.*, Jin, P.* (equal contribution), Qin, Y., Duan, R., Liu, H., de Haro, M., Nelson, D.L., and Botas, J. (2007). RNA binding proteins hnRNP A2/B1 and CUGBP1 suppress Fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS. Neuron, 16, 565-571. [PDF]

26. Jin, P.*, Duan, R., Qurashi, A., Qin, Y., Tian, D., Rosser, T.C., Liu, H., Feng, Y., and Warren, S.T.* (2007). Pur α binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of Fragile X Tremor/Ataxia Syndrome. Neuron, 16, 556-564. (*: Co-Corresponding authors) [PDF]

25. Sofola, O.A., Jin, P., Botas, J. and Nelson, D.L. (2007) Argonaute-2 dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeat. Human Molecular Genetics, 16, 2326-2332. [PDF]

24. Zhao, X., Pak, C., Smrt, R.D., and Jin, P. (2007) Epigenetics and Neural Developmental Disorders-Meeting Reports. Epigenetics, 2, 126-138. [PDF]

23. Yang, L., Duan, R., Chen, D., Wang, J., Chen, D.* and Jin, P.* (2007). Fragile X mental retardation protein modulates the fate of germline stem cells in Drosophila. Human Molecular Genetics, 16, 1814-1820. (*: Co-Corresponding authors) [PDF]

22. Duan, R., Pak, C., and Jin, P. (2007). A single nucleotide polymorphism associated with mature miRNA-125a alters the processing of pri-miRNA. Human Molecular Genetics, 16, 1124-1131. [PDF]

21. Szulwach, K. and Jin, P. (2007). Role of microRNA pathway in Fragile X Mental Retardation. microRNAs: From Basic Science to Disease Biology edited by Appasani, K., 361-369.

2006

 

20. Duan, R. and Jin, P. (2006). Identification of mRNAs and microRNAs associated with fragile X mental retardation protein. Methods in Molecular Biology, 342, 265-274. [PDF]

2005

19. Gallo, JM, Jin, P., Thornton, C.A., Lin, H., Robertson, J., D'Souza, I., and Schlaepfer, W.W. (2005). The role of RNA and RNA processing in neurodegeneration. Journal Of Neuroscience 25, 10372-10375.

18. Jin, P. (2005). Condensation and Commentary. ChemTracts-Biochemistry and Molecular Biology 18, 168-172.

17. Nakamoto, M., Jin, P., O’Donnell, W.T., and Warren, S.T. (2005) Physiological identification of human transcripts translationally regulated by a specific microRNA. Human Molecular Genetics, 14, 3813-3821.

16. Mersey, B.D., Jin, P., and Danner, D.J. (2005) Human MicroRNA (miR-29b) Expression Controls The Amount Of Branched Chain a-Ketoacid Dehydrogenase Complex In A Cell. Human Molecular Genetics, 14, 3371-3377. [PDF]

15. Zarnescu, D.C., Shan, G., Warren, S.T. and Jin, P. (2005). Come FLY with us: Towards understanding fragile X syndrome. Genes, Brain and Behavior, 4, 385-392. [PDF]

14. Zarnescu, D.C., Jin, P., Nakamoto, M., Dockendorff, T.C., Feng, Y., Jongens, T.A., Warren, S.T., and Moses, K. (2005). Fragile X and Lgl proteins form a functional complex in fly and mouse neural development. Development Cell, 8, 43-52 (Cover). [PDF]

Papers Before 2004

13. Jin, P., Alisch, R.S. and Warren, S.T. (2004). RNA and microRNAs in fragile X mental retardation. Nature Cell Biology 6, 1048-1053. [PDF]

12. Jin, P., Zarnescu, D.C., Ceman, S., Nakamoto, M., Mowrey, J., Jongens, T.A., Nelson, D.L., Moses, K., and Warren, S.T. (2004). Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nature Neuroscience, 7, 113-117. [PDF]

11. Jin, P., Zarnescu, D.C., Zhang, F., Pearson, C.E., Lucchesi, J.C., Moses, K and Warren, S.T. (2003). RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila. Neuron, 39, 739-747. [PDF]

10. Jin, P., and Warren, S. T. (2003). New insights into fragile X syndrome: from molecules to neurobehaviors. Trends Biochem Sci 28, 152-158. [PDF]

9. Sun, Y., Witte, D. P., Jin, P., and Grabowski, G. A. (2003). Analyses of temporal regulatory elements of the prosaposin gene in transgenic mice. Biochem J 370, 557-566. [PDF]

8. Jin, P., Sun, Y., and Grabowski, G. A. (2001). In vivo Roles of ROR alpha and Sp4 in the Regulation of Murine Prosaposin Gene. DNA and Cell Biology 20, 781-789. [PDF]

7. Darnell, J. C., Jensen, K. B., Jin, P., Brown, V., Warren, S. T., and Darnell, R. B. (2001). Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 107, 489-99. [PDF]

6. Brown, V.*, Jin, P.* (equal contribution), Ceman, S., Darnell, J. C., O’Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., Darnell, R. B., and Warren, S. T. (2001). Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 107, 477-87. [PDF]

5. Jin, P., and Warren, S. T. (2000). Understanding the molecular basis of fragile X syndrome. Hum Mol Genet 9, 901-8. [PDF]

4. Sun, Y., Jin, P., Witte, D. P., and Grabowski, G. A. (2000). Prosaposin: promoter analysis and central-nervous-system-preferential elements for expression in vivo. Biochem J 352 Pt 2, 549-56. [PDF]

3. Sun, Y., Jin, P., Witte, D. P., and Grabowski, G. A. (1998). Isolation and characterization of the human prosaposin promoter. Gene 218, 37-47. [PDF]

2. Jin, P., Sun, Y., and Grabowski, G. A. (1998). Role of Sp proteins and RORalpha in transcription regulation of murine prosaposin. J Biol Chem 273, 13208-16. [PDF]

1. Sun, Y., Jin, P., and Grabowski, G. A. (1997). The mouse prosaposin locus: promoter organization. DNA and Cell Biology 16, 23-34.