Publications

http://www.ncbi.nlm.nih.gov/sites/entrez?term=li%20xj%20huntington%20OR%20li%20xj%20emory

Publications from Ph.D. graduate students (bold type) in the Li lab

1.         Cornett J., Cao FL., Wang CE., Ross CA., Bates GP., Li, SH., Li X-J. Polyglutamine expansion of huntingtin impairs its nuclear export. Nature Genetics, 37:198-204, 2005

2.         Cornett J., Friedman M, Li, SH., Li X-J.  Transcriptional dysregulation and therapy of polyglutamine diseases.  Curr Med Chem, Central Nervous System Agents, 5: 119-127, 2005

3.         Shin, J. Y., Fang, Z. H., Yu, Z. X., Wang, C. E., Li, S. H. and Li, X. J. Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J Cell Biol 171: 1001-1012, 2005.

4.         McGuire JR, Li, S-H, Li, X-J.  Polyglutamine protein trafficking and neurodegeneration.  Current Genomics, 6: 189-194, 2005.

5.         Friedman M, Li SH, Li, X-J.  Polyglutamine disorders. In The Human Nucleotide Expansion Disorders Nucleic Acids and Molecular Biology pp 199-231 (Edited by M. Fry and K. Usdin, Springer-Verlag Press) 2006

6.         McGuire, J. R., Rong, J., Li, S. H. and Li, X. J. Interaction of Huntingtin-associated Protein-1 with Kinesin Light Chain: IMPLICATIONS IN INTRACELLULAR TRAFFICKING IN NEURONS.  J Biol Chem 281: 3552-3559, 2006.

7.      Rong J., McGuire J.R., Fang Z.H., Sheng G.Q., Shin J.Y., Li S.H., Li X-J. Regulation of intracellular trafficking of huntingtin associated protein-1 is critical for TrkA protein levels and neurite outgrowth. J. Neurosci. 26: 6019-30, 2006

8.         Cornett J, Smith L, Friedman M, Shin JY, Li XJ, Li SH.  Context-dependent dysregulation of transcription by mutant huntingtin.  J Biol Chem. 281: 36198-204, 2006

9.        Rong J, Li SH, Sheng GQ, Wu M, Coblitz B, Li M, Fu HA, Li XJ. 14-3-3 protein interacts with huntingtin-associated protein1 and regulates its trafficking.   J Biol Chem. 282: 4748-56, 2007

10.       Rong, J., Li, SH., Li, X.J.  Regulation of intracellular trafficking of HAP1 J. Neurosci. Res. 85:3025-9, 2007

11.       Friedman M., Fang ZH., Shah A., Goursac L., Warren S., Li SH., Li X-J. Polyglutamine domain regulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration.  Nature Neuroscience  10: 1519-28, 2007

12.       Friedman MJ, Wang CE, Li XJ, Li SH. Polyglutamine expansion reduces the association of TBP with DNA and induces DNA binding-independent neurotoxicity.  J Biol Chem. 283: 8283-90, 2008

13.       Orr AL, Li SH, Wang CE, Li H, Rong J, Xu XS, Mastroberardino PJ, Greenamyre TJ, Li X-J. N-terminal Mutant Huntingtin Associates with Mitochondria Directly and Disrupts the Interaction of Mitochondria with Trafficking Proteins.  J. Neurosci. 28: 2783-92, 2008

14.       Li X, Li H, Li X-J. Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases.  Brain Res Rev. 59: 245-252, 2008

15.       Orr AL, Huang SS, Robert MA, Reed JC, Li SH, Li X-J. Sex-dependent effect of BAG1 in ameliorating motor deficits of huntington’s disease transgenic mice. J. Biol. Chem. 283:16027-36, 2008 

16.       Tydlacka S, Wang CE, Wang XJ, Li SH, Li X-J. Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons.  J. Neurosci. 28: 13285-13295, 2008

17.      Tydlacka S, Li SH, Li X-J.  UPS in synapse: Protein folding for the synapse, Springer-Verlag, 2009

18.       Shah A, Freidman M. Huang SS, Roberts M, Li X-J, Li SH Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17.  Hum Mol Genet. 18: 4141-52, 2009.

19.       Friedman MJ, Li S, Li X-J. Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection.  J Biol Chem. 284:27944-51, 2009

20.       Havel LS, Li SH, Li X-J. Nuclear accumulation of polyglutamine disease proteins and neuropathology.  Mol Brain. 2009 Jul 3;2(1):21.

21.       Bradford J, Shin J-Y, Roberts M, Wang C-E, Li X-J, Li SH. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.  Proc Natl Acad Sci USA. 106:22480-5, 2009

22.       Bradford J, Shin J-Y, Roberts M, Wang C-E, Sheng G-Q, Li SH, Li X-J. Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.  J Biol Chem. 285:10653-61, 2010.

23.       Li X, Wang C.E, Huang SS, Xu XS, Li X-J, Li H, Li SH. Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic amino-terminal mutant huntingtin fragments.  Hum. Mol. Genet. 19:2445-55, 2010.

24.       Bradford J. Li, SH. Li X-J. Polyglutamine toxicity in non-neuronal cells.  Cell Res. 20:400-7, 2010

25.       Havel LS, Wang CE, Huang B, Wade B, Li SH, Li X-J. Preferential localization of N-terminal mutant huntingtin in striatal neurons cause neurological symptoms and is regulated by phosphorylation. Hum Mol Genet. 2011 Feb 3. [Epub ahead of print]

26.       Cape A, Chen XX, Wang CE, O’Neill A, Lin YF, He J, Xu XS, Yi H, Li H, Li SH, Li X-J. Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic beta cells.  Cell Mol Life Sci, 69:1305-17. 2012.

27.       Weng L, Lin YF, Li AL, Wang CE, Yan S, Sun M, Gaertig MA, Mitha N, Kosaka J, Wakabayashi T, Xu X, Tang B, Li S, Li XJ. Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.  J Neurosci. 33:8172-84. 2013.

28.       Xu Q.Q., Huang S.S., Song M.K., Wang C.E. Yan S., Liu X.D., Gaertig M.A., Yu. S.P., Li H., Li S.H., Li X-J. Synaptic Mutant Huntingtin Inhibits Synapsin-1 Phosphorylation and Causes Neurological Symptoms.  J. Cell Biol. 202:1123-1138, 2013.

29.       Xiang JX, Yang H, Zhao T, Sun M, Xu XS, Zhou X.F., Li SH, Li X-J. Huntingtin-Associated Protein 1 is essential for postnatal growth by regulating neurogenesis.  J Clin Invest. 2014 Jan 2;124(1):85-98.

30.       Yan S, Wang CE, Wei W, Gaertig MA, Lai L, Li S, Li X-J. TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain.  Hum Mol Genet. 23(10):2678-93. 2014.

31.       Yang S, Huang SS, Gaertig MA, Li X-J*, Li SH*. Age-dependent decrease in chaperone activity impairs MANF expression leading to Purkinje cell degeneration in inducible SCA17 mice.  Neuron, 81, 349–365 2014

32.       Wade B, Wang CE, Yan S, Bhat K, Huang B, Li SH, Li X-J. Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues.  J Neurosci. 34(25):8411-22, 2014.

33.       Huang, B, Wei, WJ, Wang,GH, Gaertig, MA, Feng, Y, Wang, W, Li, X-J* and Li, SH*. Mutant huntingtin down-regulates Myelin Regulatory Factor-mediated myelin gene expression and affects mature oligodendrocytes. Neuron, in press 2015