Professor, Department of Human Genetics
Director, Neuroscience Graduate Program
Scientific Director, Rodent Behavioral Core
Jason Schroeder, Ph.D.
Scientist, School of Medicine
Technical Director, Rodent Behavioral Core
Claire Galloway, Ph.D.
My research focuses on how the locus coeruleus, the major source of norepinephrine to the rest of the brain, is involved in Alzheimer's disease. Specifically, we use a transgenic rat model of Alzheimer's disease to investigate how pathological tau in the locus coeruleus impacts the development of cognitive impairments and spread of neuropathology in downstream brain regions, such as the hippocampus and prefrontal cortex. The goal of this research is to contribute to the development of novel therapeutics that target the earliest stages of Alzheimer's disease.
Chicora Oliver, Ph.D.
My work examines the neuroanatomical substrates of sleep and arousal, with a focus on dopaminergic cells in the ventral periaqueductal gray. Using electrophysiology, viral-vector-mediated tract tracing, and chemogenetics combined with electroencephalography, my research will elucidate novel sleep and arousal circuits with unprecedented cell-type specificity.
I am interested in exploring alternative therapies for drug addiction and post-traumatic stress disorder. My current project is testing whether unexpected, high-value natural rewards can curb reinforced cocaine-seeking and relapse-like behaviors in rats. By using operant conditioning and in vivo fast-scan cyclic voltammetry to correlate behavior with real-time dopamine release, we hope to learn how behavioral modifications can alter the value of different types of reward.
I am interested in locus coeruleus (LC) dysfunction in Alzheimer’s and Parkinson’s diseases. The LC is effected early and severely in both diseases, leading to symptoms such as depression and sleep disturbances in patients. My research goal focuses on investigating the transcriptional profile of noradrenergic neurons in the LC across disease stages. This will allow us to identify the underlying molecular mechanisms responsible for LC dysfunction in these neurodegenerative diseases.
I am generally interested in understanding the function of the locus coeruleus during health and disease. Specifically, my project focuses on the role of tau pathology in the locus coeruleus during all phases of Alzheimer’s disease. I use a combination of electrophysiology, optogenetics, and functional magnetic resonance imaging in a rat model of Alzheimer’s disease to better understand how pathology alters normal locus coeruleus function. Through this work, I hope to elucidate potential therapeutic avenues aimed at curing Alzheimer's disease.
I am in interested in advancing the understanding of the neurobiological and neurochemical mechanisms that contribute to psychiatric disorders. Currently, I am investigating the role of the locus coeruleus norepinephrine (LC-NE) system in the expression of anxiety with an emphasis on anxiety induced by exposure to novel environments. By using pharmacological and genetic manipulations of the LC-NE system, I hope to elucidate the circuits and adrenergic receptors involved in both normal and pathological anxiety states in order to develop more specific pharmacotherapies for the treatment of anxiety disorders.
I'm broadly interested in understanding the neurobiological mechanisms underlying psychiatric disorders. My project currently focuses on determining how hyperactivity of the noradrenergic locus coeruleus (LC) and release of the neuropeptide galanin from the LC may mediate depressive behavior. By using DREADDs and optogenetics in combination with various mouse strains with altered norepinephrine or galanin transmission, we hope to elucidate the role of the LC and galanin in depression.
Senior Research Specialist
Department of Human Genetics
Director of Science Education
Tennessee Aquarium, Chattanooga
Daniel Manvich, Ph.D.
Assistant Professor, Department of Cell Biology & Neuroscience
Darlene Mitrano, Ph.D.
Associate Professor, Department of Molecular Biology & Chemistry
Christopher Newport University
Kirsten Porter-Stransky, Ph.D.
Assistant Professor, Department of Biomedical Sciences
Western Michigan School of Medicine
Jacki Rorabaugh, Ph.D.
Medical Science Liason
Termpanit (Natty) Chalermpalanupap
Medical Science Liason
Debra Cooper, Ph.D.
California Senate Appropriations Committee
Alisha Epps, Ph.D.
Assistant Professor, Department of Psychology
Meriem Gaval-Cruz, Ph.D.
Research and Alliances Officer
University of Maryland Baltimore
Heather Mitchell, Ph.D.
Behavioral Core Manager, Waisman Center
University of Wisconsin-Madison
Associate Project Manager
Karen Rommelfanger, Ph.D.
Assistant Professor, Department of Neurology
Director, Neuroethics Program, Center for Ethics
Jesse Schank, Ph.D.
Associate Professor, Department of Physiology & Pharmacology
University of Georgia
Karl Schmidt, Ph.D.
Postdoctoral Fellow, Smith Lab
Kroshona Tabb, Ph.D.
Program Specialist, Geriatrics and Extended Care
Birmingham VA Medical Center
Medical College of Georgia
Anjani Chitrapu, M.D.
Pediatric Neurology Resident
Cincinnati Children's Medical Center
Boston University School of Medicine
University of Louisville School of Medicine
Mayo Clinic School of Medicine, Arizona Campus
Auburn College of Osteopathic Medicine
Johns Hopkins University
Lead Research Specialist
Emory Integrated Genomics Core Lab
Sharon Lin, M.D.
UC Davis Medical Center
Programmer, Recurse Center
Neuroscience & Behavioral Biology Major
Graduate Student, Physiology & Pharmacology
Wake Forest University
Yale School of Medicine