Professor, Department of Human Genetics
Director, Neuroscience Graduate Program
Scientific Director, Rodent Behavioral Core
Jason Schroeder, Ph.D.
Scientist, School of Medicine
Technical Director, Rodent Behavioral Core
Daniel Manvich, Ph.D.
My main research focus is to better understand the neurobiological mechanisms underlying stress-induced drug relapse. To this end, we recently developed a novel model of drug relapse in which drug-seeking behavior is elicited via exposure to social defeat, an ethologically-valid psychosocial stressor in rats. I am currently combining immunohistochemical and chemogenetic approaches to determine the neuroanatomical substrates underlying this novel drug-seeking response.
Kirsten Porter-Stransky, Ph.D.
My research focuses on catecholaminergic circuits in the brain and how they mediate motivated behaviors. One of my current projects investigates the role of locus coeruleus - ventral periaqueductal gray circuitry in modulating arousal and how dysfunctions of this circuit may be responsible for the excessive sleepiness which occurs in Parkinson's disease. My other project is examining how the protein beta-arrestin2 in nucleus accumbens neurons containing D1 or D2 dopamine receptors contributes to the behavioral effects of drugs of abuse.
Jacki Rorabaugh, Ph.D.
My project examines whether activating the locus coeruleus, a crucial source of norepinephrine and neurotrophic factors to the forebrain, can alleviate the cognitive deficits and neuropathology seen in a rat model of Alzheimer’s disease. We are able to selectively activate the locus coeruleus through viral expression of a stimulatory Designer Receptors Exclusively Activated by Designer Drugs (DREADD). We hope this work will provide the basic science backbone for using DREADD- and locus coeruleus-focused therapies to treat Alzheimer’s disease.
I am interested in exploring alternative therapies for drug addiction and post-traumatic stress disorder. My current project is testing whether unexpected, high-value natural rewards can curb reinforced cocaine-seeking and relapse-like behaviors in rats. By using operant conditioning and in vivo fast-scan cyclic voltammetry to correlate behavior with real-time dopamine release, we hope to learn how behavioral modifications can alter the value of different types of reward.
I'm broadly interested in understanding the neurobiological mechanisms underlying psychiatric disorders. My project currently focuses on determining how hyperactivity of the noradrenergic locus coeruleus (LC) and release of the neuropeptide galanin from the LC may mediate depressive behavior. By using DREADDs and optogenetics in combination with various mouse strains with altered norepinephrine or galanin transmission, we hope to elucidate the role of the LC and galanin in depression.
I am interested in sex-differences in the regulation of the glucocorticoid receptor following exposure to chronic adolescent stress, and how these changes may contribute to behavior. My project uses an adolescent stress paradigm in male and female rats to elucidate the long-term impact on glucocorticoid receptor regulation, focusing specifically the interaction of the glucocorticoid receptor and one of its co-chaperones FKBP5. In future studies I hope to determine how exposure to chronic adolescent stress impacts the behavioral effects of drugs of abuse.
Senior Research Specialist
Department of Human Genetics
Director of Science Education
Tennessee Aquarium, Chattanooga
Darlene Mitrano, Ph.D.
Assistant Professor, Department of Molecular Biology & Chemistry
Christopher Newport University
Termpanit (Natty) Chalermpalanupap
The Scienomics Groups
Debra Cooper, Ph.D.
California Senate Appropriations Committee
Alisha Epps, Ph.D.
Assistant Professor, Department of Psychology
Meriem Gaval-Cruz, Ph.D.
Regulatory Science Specialist
Cote Orphan, LLC
Heather Mitchell, Ph.D.
Behavioral Core Manager, Waisman Center
University of Wisconsin-Madison
Postdoctoral Fellow, Grady Trauma Project
Karen Rommelfanger, Ph.D.
Assistant Professor, Department of Neurology
Director, Neuroethics Program, Center for Ethics
Jesse Schank, Ph.D.
Assistant Professor, Department of Physiology & Pharmacology
University of Georgia
Karl Schmidt, Ph.D.
Postdoctoral Fellow, McElligott Lab
University of North Carolina-Chapel Hill
Kroshona Tabb, Ph.D.
Program Specialist, Geriatrics and Extended Care
Birmingham VA Medical Center
Medical College of Georgia
Anjani Chitrapu, M.D.
Pediatric Neurology Resident
Cincinnati Children's Medical Center
Boston University School of Medicine
University of Louisville School of Medicine
Johns Hopkins University
Lead Research Specialist
Emory Integrated Genomics Core Lab
Sharon Lin, M.D.
UC Davis Medical Center
Programmer, Recurse Center
Neuroscience & Behavioral Biology Major
Graduate Student, Physiology & Pharmacology
Wake Forest University
Yale School of Medicine