Rudd Laboratory

Why do chromosomes break?

DNA double-strand breaks (DSBs) can lead to either normal copy number variation, or to pathogenic chromosomal rearrangements. The Rudd lab focuses on an especially breakage-prone region of the human genome, the subtelomere, which is found at the ends of chromosomes. We are investigating the mechanisms of breakage at chromosome ends, in search of DNA sequence motifs that promote genomic instability.